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It was 1972 at Penn State University, and Gary Weber, a 29-year old materials science PhD student, had a problem with his brain. It kept generating thoughts! He had a continuous and oppressive stream of neurotic concerns about his life, his studies, and everything else. While most human beings would consider this par for the course; par for the human condition (or ‘cogito ergo sum’, which can be translated as “I think therefore I am”), Weber wouldn’t accept it. He was a scientist, a systematizer, a process guy. He liked to figure out how things worked, and how they could be tweaked to work more efficiently. And at that moment his brain wasn’t very efficient. It expended a lot of energy going over and over the same anxieties, and cravings, and storylines. “Most of these thoughts had no purpose,” he said. “They were not going to cure cancer.”